Before gaining fame on social media, Sienna was a competition dancer in her hometown of Temecula, California. She launched her Instagram account in March 2016. She joined TikTok in early 2020 and earned over 7 million views on an August 2020 TikTok POV video where she is on the set of bleachers with two friends. The video is set to the song "Forever" from HBO's Euphoria. In September 2020, she was featured by TikTok as one of the “Latinx Trailblazers”. She has her own swimwear line and merchandise store. She has been featured in campaigns by brands such as Maybelline, Levi's, IPSY, Converse, and more.

She gained popularity for the body-positive dance videos and duets she posts to her TikTok account. She has accumulated over 13 million followers on the app so far. She has a second TikTok account under the username “siennamaegomezz” and she is also known on social media by the name “spicylatina”. She is also very popular on Instagram, where she has amassed over 1.8 million followers for content such as her "Girl Likes to Eat" series. In August 2017, she shared a post alongside R&B artist Khalid on her Instagram account.

In August 2020, she collaborated on a TikTok video with Jaden Barba, a fellow influencer, with whom she grew up dancing. She is close friends with creators Sommer Ray and Summer McKeen. She appeared in a 2021 music video alongside Becky G, Julia Michaels, and Khea. She hosted a music awards show starring Lil Nas X, 24kGoldn, and other artists. Over the years she has partnered with several brands, including Maybelline, IPSY, Levis, Aerie, Reebok, and RayBan, among others. She has appeared in Access Hollywood, British Vogue, and Buzzfeed.

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